The following table shows the largest banks in Latin America in terms of total assets. The six largest banks are Brazilian financial institutions with combined assets of over US$2.0 trillion. The top 20 banks also include Mexican, Chilean and Colombian financial institutions.
| Rank | Bank | Country | Total Assets, US$b | Balance sheet |
| 1 | Banco do Brasil | Brazil | 446.354 | 30.06.2016 |
| 2 | Itau Unibanco | Brazil | 406.580 | 30.06.2016 |
| 3 | Caixa Economica Federal | Brazil | 374.815 | 30.06.2016 |
| 4 | Bradesco | Brazil | 321.786 | 30.06.2016 |
| 5 | Brazilian Development Bank | Brazil | 288.863 | 30.06.2016 |
| 6 | Santander Brasil | Brazil | 187.005 | 30.06.2016 |
| 7 | BBVA Bancomer | Mexico | 99.081 | 30.06.2016 |
| 8 | Grupo Aval (1) | Colombia | 73.482 | 30.06.2016 |
| 9 | Santander Mexico | Mexico | 68.290 | 30.06.2016 |
| 10 | Banamex | Mexico | 67.113 | 30.06.2016 |
| 11 | Banorte | Mexico | 66.958 | 30.06.2016 |
| 12 | BTG Pactual | Brazil | 65.882 | 30.06.2016 |
| 13 | Bancolombia | Colombia | 64.186 | 30.06.2016 |
| 14 | Banco Santander Chile | Chile | 55.425 | 30.06.2016 |
| 15 | Banco de Bogotá | Colombia | 51.256 | 31.03.2016 |
| 16 | BancoEstado | Chile | 50.120 | 30.06.2016 |
| 17 | Banco de Chile | Chile | 47.576 | 30.06.2016 |
| 18 | Itau CorpBanca | Chile | 47.123 | 30.06.2016 |
| 19 | Banco de Credito e Inversiones (BCI) | Chile | 45.594 | 30.06.2016 |
| 20 | Banco Safra | Brazil | 43.357 | 30.06.2016 |
| 21 | Banco de Crédito del Perú | Peru | 37.777 | 30.06.2016 |
| 22 | HSBC Mexico | Mexico | 34.179 | 30.06.2016 |
| 23 | Banco Votorantim | Brazil | 33.367 | 30.06.2016 |
| 24 | Banco de la Nacion Argentina | Argentina | 31.315 | 31.03.2016 |
| 25 | Davivienda | Colombia | 30.151 | 30.06.2016 |
| 26 | Citibank (Brasil) | Brazil | 24.624 | 30.06.2016 |
| 27 | BBVA Continental | Peru | 22.660 | 30.06.2016 |
| 28 | Banrisul | Brazil | 20.962 | 30.06.2016 |
| 29 | BBVA Chile | Chile | 20.566 | 30.06.2016 |
| 30 | Scotiabank Mexico | Mexico | 19.198 | 30.06.2016 |
| 31 | BBVA Colombia | Colombia | 17.477 | 30.06.2016 |
| 32 | Scotiabank Chile | Chile | 17.425 | 30.06.2016 |
| 33 | Bancomext | Mexico | 17.297 | 30.06.2016 |
| 34 | Scotiabank Peru | Peru | 16.610 | 30.06.2016 |
| 35 | Banco de la República Oriental del Uruguay | Uruguay | 16.490 | 31.03.2016 |
| 36 | Banco General | Panama | 15.620 | 30.06.2016 |
| 37 | Interbank | Peru | 14.170 | 30.06.2016 |
| 38 | Banco Galicia | Argentina | 13.245 | 30.06.2016 |
| 39 | Grupo Security | Chile | 13.220 | 30.06.2016 |
| 40 | Nordeste | Brazil | 13.183 | 30.06.2016 |
| 41 | Banco Provincia | Argentina | 12.884 | 30.06.2016 |
| 42 | Banco J.P. Morgan | Brazil | 12.249 | 30.06.2016 |
| 43 | BNP Paribas Brasil | Brazil | 12.180 | 30.06.2016 |
| 44 | Credit Suisse (Brasil) | Brazil | 11.594 | 30.06.2016 |
| 45 | Grupo Financiero Interacciones | Mexico | 11.454 | 30.06.2016 |
| 46 | CorpBanca Colombia | Colombia | 11.391 | 30.06.2016 |
| 47 | Banco Nacional de Costa Rica (BNCR) | Costa Rica | 11.270 | 30.06.2016 |
| 48 | Banco de Occidente | Colombia | 11.217 | 30.06.2016 |
| 49 | Banco Santander Río | Argentina | 11.037 | 30.06.2016 |
| 50 | Banco Nacional de Panamá | Panama | 10.712 | 31.03.2016 |
| 51 | FirstCaribbean International Bank | Barbados | 10.689 | 31.12.2015 |
| 52 | Republic Financial Holdings (2) | Trinidad and Tobago | 10.270 | 30.06.2016 |
| 53 | Banco Cooperativo Sicredi | Brazil | 9.743 | 31.12.2015 |
| 54 | Banco del Bajio | Mexico | 9.731 | 30.06.2016 |
| 55 | Banco de Costa Rica (BCR) | Costa Rica | 9.690 | 30.06.2016 |
| 56 | Banco Cooperativo do Brasil (Bancoob) | Brazil | 9.380 | 30.06.2016 |
| 57 | Banco del Pichincha | Ecuador | 9.258 | 30.06.2016 |
| 58 | Banistmo (3) | Panama | 9.200 | 30.06.2016 |
1 - Grupo Aval Acciones y Valores S.A. controls Banco de Bogotá, Banco de Occidente, Banco Popular and Banco AV Villas.
2 - The company was formery known as Republic Bank Ltd.
3 - Banistmo (formerly known as HSBC Bank (Panama)) operates as a subsidiary of Bancolombia.