The following are the largest U.S. Banks based on total assets as of March 31, 2011. The top 10 banks have over $11.2 trillion in combined assets. Bank of America is the largest bank in the US with assets of  nearly $2.28 trillion and total deposits of about $1 trillion. Bank of America serves over 57 million retail and small business customers through a network of over 6,000 domestic banking offices and 18,500 ATMs. JPMorgan Chase is the second-largest bank in the US by assets and the largest by market capitalization.

Note: Bank of America is no longer the largest US bank by assets. As of September 30, 2011, Bank of America had $2.22 trillion in total assets and JPMorgan Chase had about $2.29 trillion.

Rank Company Location Total assets ($b, 31/3/2011)
1 Bank of America Charlotte, NC 2,276.42
2 J.P.Morgan Chase & Co. New York, NY 2,198.16
3 Citigroup New York, NY 1,947.82
4 Wells Fargo & Company San Francisco, CA 1,244.67
5 Goldman Sachs Group New York, NY 933.471
6 Morgan Stanley New York, NY 836.185
7 Metlife New York, NY 751.341
8 Taunus Corporation New York, NY 396.741
9 HSBC North America Holdings New York, NY 369.535
10 U.S. Bancorp Minneapolis, MN 311.462
11 Bank of New York Mellon New york, NY 266.571
12 PNC Financial Services Group Pittsburgh, PA 259.501
13 Capital One Mclean, VA 199.300
14 TD Bank US Holding Company Portland, ME 184.197
15 Ally Financial Detroit, MI 173.704
16 Suntrust Banks Atlanta, GA 170.835
17 State Street Corporation Boston, MA 170.236
18 BB&T Corporation Winston-Salem, NC 157.039
19 American Express Company New York, NY 142.925
20 Citizens Financial Group Providence, RI 131.971
21 Regions Financial Corporation Birmingham, AL 131.799
22 Fifth Third Bancorp Cincinnati, OH 110.485
23 Northern Trust Corporation Chicago, IL 92.679
24 Keycorp Cleveland, OH 90.311
25 RBC USA Holdco Corporation New York, NY 85.040
26 UnionBanCal Corporation San Francisco, CA 80.642
27 Harris Financial Wilmington, DE 73.983
28 BancWest Corporation Honolulu, HI 73.464
29 M&T Bank Corporation Buffalo, NY 67.881
30 Discover Financial Services Riverwoods, IL 64.695
31 BBVA USA Bancshares Houston, TX 63.647
32 Comerica Dallas, TX 55.238
33 Huntington Bancshares Columbus, OH 52.949
34 CIT Group Livingston, NJ 50.854
35 Zions Bancorporation Salt Lake City, UT 50.810
36 Marshall & Ilsley Milwaukee, WI 49.685
37 Utrecht-America Holdings New York, NY 44.388
38 New York Community Bancorp Westbury, NY 41.048
39 Popular, inc. San Juan, PR 38.736
40 Synovus Financial Corp. Columbus, GA 28.678
41 First horizon National Corporation Memphis, TN 24.440
42 Bok Financial Corporation Tulsa, OK 23.718
43 City National Corporation Los Angeles, CA 21.639
44 Associated Banc-Corp Green Bay, WI 21.474
45 First Niagara financial Group Buffalo, NY 21.469
46 First citizens Bancshares Raleigh, NC 21.167
47 East West Bancorp Pasadena, CA 21.147
48 Commerce Bancshares Kansas City, MO 19.029
49 TCF Financial Corporation Wayzata, MN 18.734
50 Webster Financial Corporation Waterbury, CT 17.969