The following list shows the largest banks in the U.S. as of December 31, 2010. Bank of America Corporation (NYSE: BAC) and JPMorgan Chase & Co. (NYSE: JPM) are the two largest financial institutions in America based on assets.
| Rank | Company | Total Assets ($b) | Location |
| 1 | Bank of America | 2,264.9 | Charlotte, NC |
| 2 | JPMorgan Chase | 2,117.6 | New York, NY |
| 3 | Citigroup | 1,913.9 | New York, NY |
| 4 | Wells Fargo | 1,258.1 | San Francisco, CA |
| 5 | HSBC North America Holdings | 343.7 | New York, NY |
| 6 | Goldman Sachs Group | 911.3 | New York, NY |
| 7 | Morgan Stanley | 807.7 | New York, NY |
| 8 | US Bancorp | 307.8 | Minneapolis, MN |
| 9 | PNC Financial Services | 264.3 | Pittsburgh, PA |
| 10 | Bank of New York Mellon | 247.3 | New York, NY |
| 11 | Capital One Financial Corp. | 197.5 | McClean, VA |
| 12 | TD Bank US Holding | 177.0 | Portland, ME |
| 13 | SunTrust Banks | 172.9 | Atlanta, GA |
| 14 | State Street | 160.5 | Boston, MA |
| 15 | BB&T Corp. (BBT) | 157.1 | Winston-Salem, NC |
| 16 | Regions Financial Corp. | 132.4 | Birmingham, AL |
| 17 | Citizens Financial (subsidiary of Royal Bank of Scotland Group) |
130.0 | Providence, RI |
| 18 | Fifth Third Bancorp | 111.0 | Cincinnati, OH |
| 19 | KeyCorp | 91.8 | Cleveland, OH |
| 20 | Santander Holdings USA | 89.7 | Boston, MA |
| 21 | ING Bank FSB | 87.8 | Wilmington, DE |
| 22 | Northern Trust | 83.8 | Chicago, IL |
| 23 | UnionBanCal Corp. (subsidiary of Mitsubishi UFJ Financial Group) |
79.1 | San Francisco, CA |
| 24 | BancWest Corp. (subsidiary of BNP Paribas SA) | 72.8 | San Francisco, CA |
| 25 | Harris Financial Corp. (subsidiary of BMO Financial Group) |
70.2 | Chicago, IL |
| 26 | M&T Bank | 68.0 | Buffalo, NY |
| 27 | Discover Financial Services | 63.9 | Riverwoods, IL |
| 28 | BBVA USA Bancshares | 63.3 | Houston, TX |
| 29 | Hudson City Bancorp | 61.2 | Paramus, NJ |
| 30 | Charles Schwab Bank | 54.9 | Reno, NV |
| 31 | Huntington Bancshares | 53.8 | Columbus, OH |
| 32 | Comerica | 53.7 | Dallas, TX |
| 33 | Zions Bancorp | 51.0 | Salt Lake City, UT |
| 34 | Marshall & Ilsley | 50.8 | Milwaukee, WI |
| 35 | USAA FSB | 44.7 | San Antonio, TX |
| 36 | E*TRADE Bank | 44.3 | Arlington, VA |
| 37 | New York Community Bancorp | 41.2 | Westbury, NY |
| 38 | Popular Inc. (BPOP) | 38.7 | Hato Rey, PR |
| 39 | First Niagara Financial Group | 30.1 | Buffalo, NY |
| 40 | Synovus Financial | 30.1 | Columbus, GA |
| 41 | People's United Financial | 25.0 | Bridgeport, CT |
| 42 | RBC Bank (USA) | 27.6 | Raleigh, NC |
| 43 | OneWest Bank FSB | 27.2 | Pasadena, CA |
| 44 | First Horizon National | 24.7 | Memphis, TN |
| 45 | BOK Financial | 23.9 | Tulsa, OK |
| 46 | GE Money Bank (subsidiary of General Electric) | 22.7 | Draper, UT |
| 47 | First Republic Bank | 22.4 | San Francisco, CA |
| 48 | Associated Banc-Corp (ASBC) | 21.8 | Green Bay, WI |
| 49 | City National (CYN) | 21.4 | Los Angeles, CA |
| 50 | First Citizens Bcshs | 20.8 | Raleigh, NC |
| 51 | East West Bancorp | 20.7 | Pasadena, CA |
| 52 | Hancock Holding (HBHC) | 19.9 | Gulfport, MS |
| 53 | Commerce Bancshs | 18.5 | Kansas City, MO |