Following are the top debit card issuers in the United States ranked by purchase volume. Wells Fargo is the largest issuer of Visa debit cards in the U.S. As of June 10, 2016, the company had a market cap of over $245 billion.
| Visa | Purchase Volume, US$b, 2014 | |
| 1 | Wells Fargo | 161 |
| 2 | Bank of America | 155 |
| 3 | JP Morgan Chase | 119 |
| 4 | US Bank | 38 |
| 5 | PNC Bank | 37 |
| MasterCard | Purchase Volume, US$b, 2014 | |
| 1 | USAA | 26 |
| 2 | Fifth Third Bank | 20 |
| 3 | Sun Trust | 19 |
| 4 | Capital One | 19 |
| 5 | Citibank | 19 |
| Signature | Purchase Volume, US$b, 2014 | |
| 1 | Bank of America | 164 |
| 2 | Wells Fargo | 158 |
| 3 | JP Morgan Chase | 119 |
| 4 | PNC Bank | 37 |
| 5 | US Bank | 34 |
| PIN | Purchase Volume, US$b, 2014 | |
| 1 | Bank of America | 114 |
| 2 | Wells Fargo | 106 |
| 3 | JP Morgan Chase | 63 |
| 4 | PNC Bank | 19 |
| 5 | USAA | 17 |